Dr. James P. Moné

Education:

B.S., Colorado State University
M.T./A.S.C.P., Morristown Memorial Hospital
M.S. and Ph.D., Texas Tech University

Courses Taught:

BIOL 100 – General Biology
BIOL 161 – Microbiology
BIOL 463 – Virology

Areas of Specialization:

Virology, Immunology and Microbiology

Research Interest(s):

My research interests focus mainly on the study of viruses. Since coming to Millersville University in 1994, I have conducted research on bovine leukemia virus (BLV) infection in cattle. This work culminated in a publication describing a new method for diagnosing BLV infection in cattle, with a student as the senior author. My work with BLV is now being extended to study the ability of this cancer-causing retrovirus to replicate in human B-lymphocytes. In collaboration with Dr. Susan DiBartolomeis, I am studying the ecology and population dynamics of Phycodnaviruses, a large family of viruses that infect freshwater green algae. Using DNA fingerprinting and immunological techniques, Dr. DiBartolomeis and I are analyzing molecular and antigenic relationships among this diverse virus family to determine how populations of viruses change over time. Eventually we hope to understand how these viruses evolve, and the role of these viruses in aquatic ecosystems. Students with a strong interest in virology, immunology, and molecular biology may find much fertile ground for independent study and honors thesis projects.

Selected Publication(s):

Moné, J.P. and DiBartolomeis, S.M. (2003). Apoptosis: A four-week laboratory investigation for advanced molecular and cellular biology students. Cell Biology Education, Winter: 275-295.

Johnson, M, and Moné, J, 1998. Development of a syncytia inhibition assay for the detection of bovine leukemia virus infection in cattle; comparison with western blot and agar gel immunodiffusion. J Virol Methods 177-182.

1993. Spontaneously generated non-Hodgkin's lymphoma in twenty-seven simian T-cell leukemia virus type 1 antibody-positive baboons (Papio species). Lab Animal Science 43: 301-309. (with G. B. Hubbard, J. S. Allan, K.J. Davis, M. M. Leland, P.M. Banks and B. Smir).

1992. Induction of interferon and cytotoxicity by murine peritoneal macrophages exposed to glycoprotein ligands. Acta Virol. 36: 383-391. (with S. S. Lefkowitz).

1992. Simian T-cell leukemia virus type-1 infection in a captive baboon colony. AIDS Res. Human Retro. 8: 1667-1675. (with E. Whitehead, M. M. Leland, G.B. Hubbard and J. S. Allan).

1992.Serologic confirmation of simian T-cell lymphotropic virus type I infection by using immunoassays developed for human T-lymphotropic virus antibody detection. J. Clin. Microbiol. 30: 858-861. (with D. L. Rudolph, J. Yee, S. K. Foung, J. J. Lipka, G. R. Reyes, K. Hadlock, L. Chan, F. Villinger, M.D. Lairmore, S. Sinha and R.B. Lal).

1989. Peroxidases enhance macrophage- mediated cytotoxicity via induction of tumor necrosis factor. Proc Soc. Exp. Med. Biol. 190: 144-149. (with D. L. Lefkowitz, K. Mills, T. Hsieh and S. S. Lefkowitz).