Analytical Chemistry Research

Analytical Chemistry Research

Andrea Z

Synthesis of a Fluorescence Cu (II) Sensor

Student Researcher: Andrea Zeppuhar
Faculty Advisor: Dr. Maria V. Schiza

This research project investigates the synthesis of a fluorescence copper (II) sensor. This is of importance due to the biological and environmental implications of copper (II) in numerous neurodegenerative diseases and ecological pollution. This sensor depends on an “off-on” system that separates sensing by using two different fluorogenic ligands that are capable of metal chelation. One of the ligands binds to copper (II) while the other produces a fluorescent signal to report the binding. The system contains an equimolar quantity of cadmium (II), and when copper (II) is introduced into the system, cadmium (II) is displaced from one ligand to the other and copper (II) will bind to the ligand that cadmium (II) was originally bound to. This will cause the signal from the copper (II)-ligand 1 to decrease while the signal of cadmium (II)-ligand 2 to increase at the same time, creating an “off-on” system for the detection of the metal of interest. This system can be applied to the synthesis of other metal ion sensors as well.


Taylor K

Synthesis of Variable Size Silver Nanoprisms

Student Researcher: Taylor M. Keller
Faculty Advisor: Dr. Maria V. Schiza

The objective of this project is to synthesize silver nanoprisms with variable size control. Bromide ions will be used for size control because they are known to strongly bind to a silver surface forming silver bromide, which prevents further growth of silver particles. The optical properties of the synthesized nanoprisms will be measured using UV-visible spectroscopy. Further research will be done on the application of these nanoprisms on the enhanced detection of analytes using Raman spectroscopy.