Functionalized Biodegradable Nanoparticles for Targeted Drug Delivery
Student Researcher: Bill Rutledge
Faculty Advisor: Dr. Jeremiah K.N. Mbindyo
The goal is of the research is to develop methods for targeted drug delivery using interactions between small ligand molecules and cell surface receptors. Binding of streptavidin to biotin bound on polylactic acid nanoparticles will be investigated. The methods developed will be extended to folate-folate binding protein interactions, which are of interest in targeted drug delivery. Characterization methods will include transmission electron microscopy (TEM), UV/VIS spectroscopy, scanning electron microscopy (SEM), and atomic force microscopy (AFM).