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Organic Chemistry Research

Organic Chemistry Research

Janelle B

Studies Toward the Synthesis of Hunanamycin A and its Derivatives

Student Researcher: Janelle Biehl
Faculty Advisor: Dr. Steven Kennedy

The goal of this research is to synthesize Hunanamycin A from commercially available chemicals. Hunanamycin A is a natural product recently isolated from Bacillus hunanensis. It can kill the pathogens Salmonella and E. coli. Test reactions will be run on model systems to explore multiple ways of synthesizing the target product. From the complete synthesis further biological testing can be done to check for other antibacterial properties.

John N

Studies Toward the Synthesis of Hunanamycin A and its Derivatives

Student Researcher: John Noyes
Faculty Advisor: Dr. Steven Kennedy

Hunanamycin A (HA) has been found to have antibacterial properties for various pathogens such as Salmonella and E. coli. The goal of this research is to synthesize HA as well as other derivatives of HA for further biological studies. Emphasis will be placed on developing an efficient route to HA and discovering new derivatives of HA.

Brandon P

Diaziridines II. The Synthesis and Chemistry of Novel 1-Aryl-1-trimethylsilyl-1H-diazirino-[1,2-b]phthalazine-3,8-diones.

Student Researcher: Brandon Peiffer
Faculty Advisor: Dr. Steven M. Bonser

Another objective in my Laboratory is to develop some novel diaziridine compounds that can be used to make specific therapeutic molecules of diverse architecture, and their subsequent development into useful pharmaceuticals.  The targeted therapeutic/medicinal molecules of interest are the lesser known 2,4-benzodiazepines, a class of compounds known for their anxiolytic/antiarrhythmic activity.  Benzodiazepines, in general, are Central Nervous System (CNS) depressants prescribed for treating anxiety, tension, muscle spasms, alcohol withdrawal, and insomnia.  The 1,4-benzodiazepines are the most common class, and are exemplified by diazepam, trade name valium.  We plan to utilize a new approach to synthesizing specific diaziridines that may provide a more robust, cost-effective entry into the 2,4-benzodiazepine anxiolytic pharmaceuticals.  This new approach will exploit the reaction between certain chloro-diaziridines, obtained from amidines, with certain 1,2-diaroyl dichloride and 1,2-dibenzenesulfonyl dichloride compounds to generate the specific “designer” diaziridines needed for this study.