Office: Caputo 305A
M: 9 - 10 am & 1 - 2 pm
W: 9:30 - 11:30 am
F: 10 - 11 am
Comments: Other office hours by appointment.
M.S. in Biology, Environmental Biology, University of Lodz, Poland
M.S. in Biology, Genetics, University of Lodz, Poland
Ph.D. in Molecular Biology, Princeton University
BIOL 101 – Foundations of Biology
BIOL 472 – Introduction to Epigenetics
Areas of Specialization:
Genetics, Molecular Biology, Epigenetics, Plant Biology
My research focuses on epigenetics, a science studying heritable changes in phenotype not caused by changes in DNA sequence, in plants. I’m especially interested in an epigenetic phenomenon known as gene imprinting. Gene imprinting is found in mammals and flowering plants where a subset of genes is expressed from only one copy in a parent-of-origin dependent manner, with either the copy inherited from the mother or the one from the father being active. In plants, imprinted gene expression takes place in seeds, and can be potentially important for agriculture. Gene imprinting is well described in a few species under optimal growth conditions; however, it is not known how it is influenced by environmental stress. My research involves studying changes to imprinted gene expression under heat, drought and other stresses in the plant model species, Arabidopsis thaliana, using molecular biology and genetic techniques and bioinformatics. I aim to determine how dynamic gene imprinting is under diverse growth conditions and whether it could play an adaptive role under environmental stress.
Klosinska M., Picard C., Gehring M. (2016) Conserved imprinting associated with unique epigenetic signatures in the Arabidopsis genus. Nat Plants 2:16145
Klosinska M., Crutchfield C., Bradley P., Rabinowitz J., Broach J. (2011) Yeast cells can access distinct quiescent states. Genes Dev. 25, 336-49
Klosinska M., Blasiak J. (2004) Triple-stranded DNA and its applications. (review) Postepy Biologii Komorki 31, 647-661